Main Article Content
Introduction: Many asthmatics complain of worsening respiratory symptoms during periods of stress.
This study evaluated the relationship among asthma symptoms, lung physiology, inflammatory parameters
and perceived cognitive stress and quality of life in healthy adult students. This relationship was assessed
at two time points: a time of normal activity and at a time of cognitive stress during academic examinations.
Methods: Subjects attended the University of Alberta Hospital for a screening visit, which included a
clinical exam, spirometry, methacholine challenge, allergen skin tests to assess atopy status and Mini
International Neuropsychiatric Interview (MINI). Eligible subjects returned for a low stress visit (LSV) at
least 14 days prior to an exam and a high stress visit (HSV) within 24 hours of an exam. Spirometry, and
methacholine challenge were performed during both LSV and HSV along with the collection of urine (tested
for cortisol), and the administration of 4 questionnaires to assess perceived stress and quality of life.
Results: Subjects showed no significant change in psychosocial or quality of life questionnaires between
LSV and HSV. No significant change was noted in lung function or urine cortisol. There was an unexpected
high rate of pre-existing psychiatric comorbidities in this population (based on the MINI screen failure rate).
Conclusion: We did not find a significant change in quality of life, psychosocial wellbeing or pulmonary
function or inflammation, measured by urine cortisol, during a high stress period. The high rate of
comorbidities would be important to consider as part of evaluation used in clinical asthma studies in the future.
Spectrum encourages authors to publish their work under a Creative Commons Attribution 4.0 International licence (CC BY 4.0) that allows others to distribute, remix, tweak, and build upon the work, even commercially, as long as they credit the Author(s) for the original creation. Authors may, however, choose to have their work distributed under any of the Creative Commons licenses currently available by specifying their preferred licence in the publication agreement. The applicable Creative Commons license icon will appear on the title page of each published submission. A description of the Creative Commons licences is available here: https://creativecommons.org/licenses/